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The article briefl y overviews the developments around the concepts of sustainability and sustainable development, and their current relevance in face of ever more globalised subsequent crises of fi nancial, economic and environmental nature. It appears that what learnt in the global change science could be integrated in the mainstream of sustainability analysis to develop a new paradigm of Sustainability Science, a trans-disciplinary environment in which current and future challenges of the Planet could be successfully tackled. Such science should fi nd its role in university curricula in order to contribute to training of future generations of experts and researchers who may overcome our current limitations in understanding and managing the complexity of global challenges.