The present manuscript reports on two studies focused on the lockdown experience due to the Covid-19 outbreak for parents of children with disabilities. The first study investigated the impact of the Covid-19-related rehabilitation services lockdown on the mental health of 84 caregivers through an online survey. Concerns for the child left without rehabilitation programs was one of the greatest sources of distress for caregivers and was significantly associated with caregivers’ reports of parenting stress, depression and anxiety. The second study describes the evaluation of 36 parents who received the EnFORCE tele-rehabilitation program. Parents reported benefits for both children and themselves, and little challenges using telehealth. These families should be considered as a high-risk population that requires dedicated healthcare attention, such as promoting continuity of care by investing in tele-rehabilitation programs.